Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma

Description

PRIMARY OBJECTIVE:

I. Assess if dietary replacement with magnesium rich foods and topical magnesium replacement improves serum magnesium levels in patients with a history of a lymphoproliferative disorder, not on active myelosuppressive chemotherapy, and have a serum magnesium levels 1.5 – 1.9 mg/dL.

SECONDARY OBJECTIVES:

I. Evaluate the compliance of a diet rich in magnesium as well as compliance with topical magnesium replacement in lymphoma patients who have completed therapy and are in remission.

II. Assess feasibility of enrolling patients with a history of lymphoproliferative disorder, not on active treatment with low magnesium levels.

III. Assess tolerability and toxicity of a magnesium rich diet with and without topical magnesium replacement.

EXPLORATORY OBJECTIVES:

I. Assess quality of life in patients receiving magnesium replacement with diet and/or topical magnesium.

II. Evaluate whether magnesium replacement strategies are equally effective between ethnicities.

OUTLINE:

CYCLE 1: Participants consume magnesium rich foods orally (PO) daily for 28 days.

CYCLE 2: Participants with a magnesium level between 1.5-2.1 mg/dL at the end of cycle 1 are assigned to Arm I. Patients with a magnesium level between 2.2-2.3 mg/dL at the end of cycle 1 are assigned to Arm II. Patients with a magnesium level < 1.5 mg/dL at the end of cycle 1 go off study.

ARM I: Participants continue consuming magnesium rich foods PO daily and apply Ancient Minerals Magnesium Lotion topically daily for 28 days.

ARM II: Participants continue consuming magnesium rich foods PO daily for 28 days.