FID-007 in Treating Participants With Advanced Solid Tumors

Description

PRIMARY OBJECTIVES:

I. To determine the maximum tolerated dose (MTD) of FID-007 and the recommended phase II dose (RP2D).

II. To determine the pharmacokinetics of paclitaxel, (free and total) in patients treated with FID-007.

SECONDARY OBJECTIVES:

I. To characterize the safety and tolerability of FID-007 by assessing toxicities per Common Terminology Criteria for Adverse Events (CTCAE) version (v.)4.3.

II. To obtain a preliminary assessment of anti-tumor activity of FID-007 via objective radiologic tumor response using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

EXPLORATORY OBJECTIVES:

I. To evaluate in a preliminary fashion the serum concentration of total paclitaxel and free paclitaxel, and explore potential associations with serum concentrations, efficacy and toxicity.

OUTLINE: This is a dose escalation study.

Participants receive FID-007 intravenously (IV) over 60 minutes on days 1, 8 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, participants are followed up periodically.