Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
Description
There are two conditioning regimens in this protocol for children >6 months. Alemtuzumab (Campath), Fludarabine and Melphalan are used. The regimens differ by the timing and dosing of Alemtuzumab (Campath). The two timings are distal and intermediate.
* Distal campath is initiated 22 days prior to the allogeneic transplant.
* Intermediate campath is initiated 14 days prior to allogeneic transplant.
The conditioning regimen for children with immunodeficiencies <6 months omits melphalan, and substitutes two days of busulfan. This regimen is successfully used in the United Kingdom, and has been successful in a 3 month old infant at the Children's Hospital of Philadelphia (CHOP) who engrafted with a haploidentical donor.
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